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Nausea was more frequent with tirzepatide vs placebo, especially with tirzepatide 15 mg (OR 5.60 [95% CI 3.12, 10.06]), associated with higher incidence of vomiting (OR 5.50 [95% CI 2.40, 12.59]) and diarrhoea (OR 3.31 [95% CI 1.40, 7.85])

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The inclusion is expected to improve global access and affordability, particularly in low- and middle-income nations, where diabetes management remains a significant challenge

The study, A Study of Tirzepatide in Participants With Obesity or Overweight With Weight Related Comorbidities (SURMOUNT-5), has the primary outcome of percent weight change from baseline in body weight over a 72-week period